TRPV4 is functionally expressed in oligodendrocyte precursor cells and enhances their proliferation
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چکیده
منابع مشابه
Caffeoylquinic Acid Enhances Proliferation of Oligodendrocyte Precursor Cells
This report evaluates the protective effect of caffeoylquinic acid (CA) injury to oligodendrocyte precursor cells (OPCs) by promoting the formation of oligodendrocytes. Neonatal rat brain was used to isolate primary OPCs and non-lethal CoCl2 was used to induce hypoxic stress to inhibit the differentiation of OPCs. Differentiation of OPCs was estimated by survival assay and the expressions of my...
متن کاملKV7/KCNQ Channels Are Functionally Expressed in Oligodendrocyte Progenitor Cells
BACKGROUND K(V)7/KCNQ channels are widely expressed in neurons and they have multiple important functions, including control of excitability, spike afterpotentials, adaptation, and theta resonance. Mutations in KCNQ genes have been demonstrated to associate with human neurological pathologies. However, little is known about whether K(V)7/KCNQ channels are expressed in oligodendrocyte lineage ce...
متن کاملNG2 expressed by macrophages and oligodendrocyte precursor cells is dispensable in experimental autoimmune encephalomyelitis.
Increased expression of the chondroitin proteoglycan NG2 is a prominent feature in central nervous system injury with unknown cellular source and biological relevance. Here, we describe the first detailed analysis of experimental autoimmune encephalomyelitis in NG2 knockout mice and NG2 knockout bone marrow chimeras. We show that both macrophages and oligodendrocyte progenitor cells express and...
متن کاملPH20 is not expressed in murine CNS and oligodendrocyte precursor cells
OBJECTIVE Expression of Spam1/PH20 and its modulation of high/low molecular weight hyaluronan substrate have been proposed to play an important role in murine oligodendrocyte precursor cell (OPC) maturation in vitro and in normal and demyelinated central nervous system (CNS). We reexamined this using highly purified PH20. METHODS Steady-state expression of mRNA in OPCs was evaluated by quanti...
متن کاملComment on: PH20 is not expressed in murine CNS and oligodendrocyte precursor cells
Comment on: PH20 is not expressed in murine CNS and oligodendrocyte precursor cells Larry S. Sherman* & Stephen A. Back Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon Department of Pediatrics, Oregon Health & Science University, Portland, Oregon Depart...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2018
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.wcp2018.0_po1-1-107